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Anatomy of the episodic buffer: a voxel-based morphometry study in patients with dementia

In 2000 Baddeley proposed the existence of a new component of working memory, the episodic buffer, which should contribute to the on-line maintenance of integrated memory traces. The author assumed that this component should be critical for immediate recall of a short story that exceeds the capacity of the phonological store. Accordingly, patients with Alzheimer's dementia (AD)...

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English / 01/01/2008

Shared neural resources between music and language indicate semantic processing of musical tension-resolution patterns

Harmonic tension-resolution patterns have long been hypothesized to be meaningful to listeners familiar with Western music. Even though it has been shown that specifically chosen musical pieces can prime meaningful concepts, the empirical evidence in favor of such a highly specific semantic pathway has been lacking. Here we show that 2 event-related potentials in response to harmonic...

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English / 01/01/2008

A governance perspective on the European neighbourhood policy: integration beyond conditionality?

Inspired by the experience of Eastern enlargement, much of the academic debate on EU external relations and the European neighbourhood policy conceives of external influence in terms of the Union’s ability to induce third countries’ adaptation to predetermined EU norms and regulations. This article introduces a more structural perspective on EU external influence that scru- tinizes...

Institution partenaire

Université de Genève

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English / 01/01/2008

The Migration–Development Nexus in EU External Relations

The linkage of development cooperation with migration policies has been promoted widely by international organizations from 2000 onwards. This paper analyses the factors that have prompted and impeded a reorientation of the dominant migration policy-frame within the EU towards the realization of a migration– development nexus. It is argued that external events such as the...

Institution partenaire

Université de Genève

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English / 01/01/2008

Strong reciprocity and the roots of human morality

Human morality is a key evolutionary adaptation on which human social behavior has been based since the Pleistocene era. Ethical behavior is constitutive of human nature, we argue, and human morality is as important an adaptation as human cognition and speech. Ethical behavior, we assert, need not be a means toward personal gain. Because of our nature as moral beings, humans take...

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English / 01/01/2008

Interhemispheric effect of parietal TMS on somatosensory response confirmed directly with concurrent TMS-fMRI

Transcranial magnetic stimulation (TMS) has been used to document some apparent interhemispheric influences behaviorally, with TMS over the right parietal cortex reported to enhance processing of touch for the ipsilateral right hand (Seyal et al., 1995). However, the neural bases of such apparent interhemispheric influences from TMS remain unknown. Here, we studied this directly by...

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English / 01/01/2008

Parietal stimulation decouples spatial and feature-based attention

Everyday visual scenes contain a vast quantity of information, only a fraction of which can guide our behavior. Properties such as the location, color and orientation of stimuli help us extract relevant information from complex scenes (Treisman and Gelade, 1980; Livingstone and Hubel, 1987). But how does the brain coordinate the selection of such different stimulus characteristics?...

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English / 01/01/2008

Mapping causal interregional influences with concurrent TMS-fMRI

Transcranial magnetic stimulation (TMS) produces a direct causal effect on brain activity that can now be studied by new approaches that simultaneously combine TMS with neuroimaging methods, such as functional magnetic resonance imaging (fMRI). In this review we highlight recent concurrent TMS-fMRI studies that illustrate how this novel combined technique may provide unique insights...

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English / 01/01/2008

Graph-partitioned spatial priors for functional magnetic resonance images

Spatial models of functional magnetic resonance imaging (fMRI) data allow one to estimate the spatial smoothness of general linear model (GLM) parameters and eschew pre-process smoothing of data entailed by conventional mass-univariate analyses. Recently diffusion-based spatial priors [Harrison, L.M., Penny, W., Daunizeau, J., and Friston, K.J. (2008). Diffusion-based spatial priors...

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English / 01/01/2008

Reward facilitates tactile judgments and modulates hemodynamic responses in human primary somatosensory cortex

Reinforcing effects of reward on action are well established, but possible effects on sensory function are less well explored. Here, using functional magnetic resonance imaging, we assessed whether reward can influence somatosensory judgments and modulate activity in human somatosensory cortex. Participants discriminated electrical somatosensory stimuli on an index finger with...

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English / 01/01/2008

Dorsal premotor cortex exerts state-dependent causal influences on activity in contralateral primary motor and dorsal premotor cortex

During voluntary action, dorsal premotor cortex (PMd) may exert influences on motor regions in both hemispheres, but such interregional interactions are not well understood. We used transcranial magnetic stimulation (TMS) concurrently with event-related functional magnetic resonance imaging to study such interactions directly. We tested whether causal influences from left PMd upon...

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English / 01/01/2008

Distinct causal influences of parietal versus frontal areas on human visual cortex: evidence from concurrent TMS-fMRI

It has often been proposed that regions of the human parietal and/or frontal lobe may modulate activity in visual cortex, for example, during selective attention or saccade preparation. However, direct evidence for such causal claims is largely missing in human studies, and it remains unclear to what degree the putative roles of parietal and frontal regions in modulating visual...

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English / 01/01/2008

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