Publications des institutions partenaires
Human neural learning depends on reward prediction errors in the blocking paradigm
Learning occurs when an outcome deviates from expectation (prediction error). According to formal learning theory, the defining paradigm demonstrating the role of prediction errors in learning is the blocking test. Here, a novel stimulus is blocked from learning when it is associated with a fully predicted outcome, presumably because the occurrence of the outcome fails to produce a…
Institution partenaire
English / 01/01/2006
Earlier development of the accumbens relative to orbitofrontal cortex might underlie risk-taking behavior in adolescents
Adolescence has been characterized by risk-taking behaviors that can lead to fatal outcomes. This study examined the neurobiological development of neural systems implicated in reward-seeking behaviors. Thirty-seven participants (7-29 years of age) were scanned using event-related functional magnetic resonance imaging and a paradigm that parametrically manipulated reward values. The…
Institution partenaire
English / 01/01/2006
Anterior cingulate and posterior parietal cortices are sensitive to dissociable forms of conflict in a task-switching paradigm
The conflict-monitoring hypothesis posits that anterior cingulate cortex (ACC) monitors conflict in information processing and recruits dorsolateral prefrontal cortex (DLPFC) to resolve competition as needed. We used fMRI to test this prediction directly in the context of a task-switching paradigm, in which subjects responded to the color or the motion of a visual stimulus. Conflict…
Institution partenaire
English / 01/01/2006
Anterolateral prefrontal cortex mediates the analgesic effect of expected and perceived control over pain
Perceived control attenuates pain and pain-directed anxiety, possibly because it changes the emotional appraisal of pain. We examined whether brain areas associated with voluntary reappraisal of emotional experiences also mediate the analgesic effect of perceived control over pain. Using functional magnetic resonance imaging, we compared self-controlled noxious stimuli with…
Institution partenaire
English / 01/01/2006
Acute changes in frontoparietal activity after repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex in a cued reaction time task
Lesion and functional imaging studies in humans have suggested that the dorsolateral prefrontal cortex (DLPFC), ventrolateral prefrontal cortex (VLPFC), and intraparietal sulcus (IPS) are involved in orienting attention. A functional magnetic resonance imaging study supplemented by a behavioral experiment examined the effects of 5 Hz repetitive transcranial magnetic stimulation (rTMS…
Institution partenaire
English / 01/01/2006
Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network
In fear extinction, an animal learns that a conditioned stimulus (CS) no longer predicts a noxious stimulus [unconditioned stimulus (UCS)] to which it had previously been associated, leading to inhibition of the conditioned response (CR). Extinction creates a new CS-noUCS memory trace, competing with the initial fear (CS-UCS) memory. Recall of extinction memory and, hence, CR…
Institution partenaire
English / 01/01/2006
The left parietal cortex and motor intention: an event-related functional magnetic resonance imaging study
Traditionally the posterior parietal cortex was believed to be a sensory structure. More recently, however, its important role in sensory-motor integration has been recognized. One of its functions suggested in this context is the forming of intentions, i.e. high-level cognitive plans for movements. The selection and planning of a specific movement defines motor intention. In this…
Institution partenaire
English / 01/01/2006
Task and content modulate amygdala-hippocampal connectivity in emotional retrieval
The ability to remember emotional events is crucial for adapting to biologically and socially significant situations. Little is known, however, about the nature of the neural interactions supporting the integration of mnemonic and emotional information. Using fMRI and dynamic models of effective connectivity, we examined regional neural activity and specific interactions between…
Institution partenaire
English / 01/01/2006
Models of functional neuroimaging data
Inferences about brain function, using functional neuroimaging data, require models of how the data were caused. A variety of models are used in practice that range from conceptual models of functional anatomy to nonlinear mathematical models of hemodynamic responses (e.g. as measured by functional magnetic resonance imaging, fMRI) and neuronal responses. In this review, we discuss…
Institution partenaire
English / 01/01/2006
Synaptic plasticity and dysconnection in schizophrenia
Current pathophysiological theories of schizophrenia highlight the role of altered brain connectivity. This dysconnectivity could manifest 1) anatomically, through structural changes of association fibers at the cellular level, and/or 2) functionally, through aberrant control of synaptic plasticity at the synaptic level. In this article, we review the evidence for these theories,…
Institution partenaire
English / 01/01/2006
Empathic neural responses are modulated by the perceived fairness of others
The neural processes underlying empathy are a subject of intense interest within the social neurosciences. However, very little is known about how brain empathic responses are modulated by the affective link between individuals. We show here that empathic responses are modulated by learned preferences, a result consistent with economic models of social preferences. We engaged male…
Institution partenaire
English / 01/01/2006
Nicotinic modulation of human auditory sensory memory: Evidence from mismatch negativity potentials
Impairment in mismatch negativity (MMN) generation is a robust biological marker of schizophrenia. Understanding the physiological and pharmacological processes involved in its generation may therefore advance our understanding of this complex disorder. The present study tested if acute administration of nicotine modulates human auditory sensory memory as measured with MMN. ERP…
Institution partenaire
English / 01/01/2006
A role for Broca's area beyond language processing: Evidence from neuropsychology and fMRI
Broca's area (or, more generally, the left inferior frontal region) is implicated in many language and language-related tasks. This chapter addresses the question of whether it is legitimate to move from this assertion (supported by very large numbers of lesion studies and functional neuroimaging experiments) to the theoretical claim that the exclusive (or even the core)…
Institution partenaire
English / 01/01/2006
Open innovation in systemic innovation contexts
Institution partenaire
English / 01/01/2006
A dynamic segmentation approach for targeting and customizing direct marketing campaigns
An important aspect of customer relationship management is the targeting of customer segments with tailored promotional activities. While most contributions focus on the selection of promising customers for targeting, only few authors address the question of which specific differential offers to direct to the selected target groups. We focus on both issues and propose a flexible, two…
Institution partenaire
English / 01/01/2006
Coordination in a Repeated Stochastic Game with Imperfect Monitoring
We consider a repeated stochastic coordination game with imperfect public monitoring. In the game any pattern of coordinated play is a perfect Bayesian Nash equilibrium. Moreover, standard equilibrium selection argumentsneither have no bite or they select an equilibrium that is not observed in actual plays of the game. We give experimental evidence for a unique equilibrium selection…
Institution partenaire
English / 01/01/2006
Heterogeneous social preferences and the dynamics of free riding in public goods
"We provide a direct test of the role of social preferences in voluntary cooperation. We elicit individuals’ cooperation preference in one experiment and make a point prediction about the contribution to a repeated public good. This allows for a novel test as to whether there are ""types"" of players who behave consistently with their elicited preferences. We…
Institution partenaire
English / 01/01/2006
Resampling vs. Shrinkage for Benchmarked Managers
A well-known pitfall of Markowitz (1952) portfolio optimization is that the sample covariance matrix, which is a critical input, is very erroneous when there are many assets to choose from. Ifnunchecked, this phenomenon skews the optimizer towards extreme weights that tend to performnpoorly in the real world. One solution that has been proposed is to shrink the sample covariance…
Institution partenaire
English / 01/01/2006
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