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Assessing statistical significance in multivariable genome wide association analysis

Motivation: Although Genome Wide Association Studies (GWAS) genotype a very large number of single nucleotide polymorphisms (SNPs), the data is often analyzed one SNP at a time. The low predictive power of single SNPs, coupled with the high significance threshold needed to correct for multiple testing, greatly decreases the power of GWAS.
Results: We propose a procedure in…

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English / 01/01/2016

Attentional Bias towards Positive Emotion Predicts Stress Resilience

There is extensive evidence for an association between an attentional bias towards emotionally negative stimuli and vulnerability to stress-related psychopathology. Less is known about whether selective attention towards emotionally positive stimuli relates to mental health and stress resilience. The current study used a modified Dot Probe task to investigate if individual…

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English / 01/01/2016

Carbon taxes, path dependency, and directed technical change: evidence from the auto industry

Can directed technical change be used to combat climate change? We construct new firm-level panel data on auto industry innovation distinguishing between “dirty” (internal combustion engine) and “clean” (e.g., electric, hybrid, and hydrogen) patents across 80 countries over several decades. We show that firms tend to innovate more in clean (and less in dirty) technologies when they…

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English / 01/01/2016

Import competition and the great US employment sag of the 2000s

Even before the Great Recession, US employment growth was unimpressive. Between 2000 and 2007, the economy gave back the considerable employment gains achieved during the 1990s, with a historic contraction in manufacturing employment being a prime contributor to the slump. We estimate that import competition from China, which surged after 2000, was a major force behind both recent…

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English / 01/01/2016

Unmet aspirations as an explanation for the age U-shape in wellbeing

An emerging economic literature has found evidence that wellbeing follows a U-shape over age. Some theories have assumed that the U-shape is caused by unmet expectations that are felt painfully in midlife but beneficially abandoned and experienced with less regret during old age. This paper is the first to analyze age patterns in unmet expectations. Using the German Socio-Economic…

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English / 01/01/2016

Cognitive biases associated with medical decisions : a systematic review

Background Cognitive biases and personality traits (aversion to risk or ambiguity) may lead to diagnostic inaccuracies and medical errors resulting in mismanagement or inadequate utilization of resources. We conducted a systematic review with four objectives: 1) to identify the most common cognitive biases, 2) to evaluate the influence of cognitive biases on diagnostic accuracy or…

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English / 01/01/2016

The 9/11 dust cloud and pregnancy outcomes: a reconsideration

The events of 9/11 released a million tons of toxic dust into lower Manhattan, an unparalleled environmental disaster. It is puzzling, then, that the literature has shown little effect of fetal exposure to the dust. However, inference is complicated by preexisting differences between the affected mothers and other NYC mothers as well as heterogeneity in effects on boys and girls.…

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English / 01/01/2016

Combining multiple hypothesis testing with machine learning increases the statistical power of genome-wide association studies

The standard approach to the analysis of genome-wide association studies (GWAS) is based on testing each position in the genome individually for statistical significance of its association with the phenotype under investigation. To improve the analysis of GWAS, we propose a combination of machine learning and statistical testing that takes correlation structures within the set of…

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English / 01/01/2016

How and when customer feedback influences organizational health

Purpose
– The purpose of this paper is to explore how and when customers influence organizational climate and organizational health through their feedback. Based on affective events theory, the authors classify both positive and negative customer feedback (PCF and NCF) as affective work events. The authors expect that these events influence the positive affective climate of…

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English / 01/01/2016

Regional migration governance

Institution partenaire

Université de Genève

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English / 01/01/2016

The Consequences of Social Movements

Social movements have attracted much attention in recent years, both from scholars and among the wider public. This book examines the consequences of social movements, covering such issues as the impact of social movements on the life course of participants and the population in general, on political elites and markets, and on political parties and processes of social movement…

Institution partenaire

Université de Genève

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English / 01/01/2016

Statistical Discrimination

Racial discrimination uses race as grounds to discriminate in the treatment owed to others; sexual discrimination uses people’s sexual features as grounds for determining how they should be treated compared to others. Analogously, statistical discrimination treats statistical inferences about the groups to which individuals belong as grounds for discriminating amongst them in thought…

Institution partenaire

Université de Genève

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English / 01/01/2016

Studying policy advocacy through social network analysis

Social Network Analysis (SNA) conceptualizes a policy-making process as a network of actors. It can assess if an interest group (IGs) occupies a leading central position within this policy network, if it belongs to various ad hoc coalitions or if it plays a brokering role between different stakeholders. Such network variables are crucial to capture how IGs mobilize and gain access to…

Institution partenaire

Université de Genève

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English / 01/01/2016

Enlightenment and solidarity: National union movements, distributive norms and the union effect on support for redistribution

Using data from the European Social Survey (2002-14), this paper explores the effect of union membership on support for redistribution. We hypothesize that the wage-bargaining practices of unions promote egalitarian distributive norms among low-wage and high-wage union members alike and that distributive norms in turn lead union members to support redistribution. Consistent with our…

Institution partenaire

Université de Genève

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English / 01/01/2016

Biographical Impact

Institution partenaire

Université de Genève

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English / 01/01/2016

The biographical impact of participation in social movement activities: beyond highly committed New Left activism

Studying the outcomes of social movements is important if we want to elucidate the role of collective action in society. While most works have addressed aggregate-level political outcomes such as changes in laws or new policies, a relatively small but substantial body of literature deals with the personal and biographical consequences of social movements at the micro-level, that is,…

Institution partenaire

Université de Genève

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English / 01/01/2016

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